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A Popular Science Article on Approaches to Clearing Senescent Cells
The development of senolytic therapies, capable of selectively destroying senescent cells in old tissues, is a very promising area of medicine. When present even in comparatively small numbers, senesc...
The Relationship Between Sarcopenia and Cardiovascular Disease
Sarcopenia is the progressive loss of muscle mass and strength that takes place in later life. Both sarcopenia and cardiovascular disease are accelerated by the chronic inflammation of aging, but the ...
Vascular Stiffness and Its Contribution to Age-Related Disease
The largest cause of human mortality is cardiovascular disease. Further, looking beyond all of the deaths clearly defined as a failure of the cardiovascular system - such as stroke, heart attack, hear...
Lower Serum Klotho Correlates with Longer Sleep Duration in Older People
Higher levels of klotho slow aging in animal models, most likely largely a result of improved kidney function in later life. Klotho upregulation also slows cognitive aging, which may be downstream of ...
Epigenetic Age Acceleration Is Not Associated with Age-Related Macular Degeneration
Researchers here show that present epigenetic clocks perform poorly in the context of retinal aging and the dysfunction of age-related macular degeneration. Epigenetic age acceleration is the differen...
Longevity.Technology Looks Back at 2021
A fair number of news and interest sites covering aging research and the development of therapies to treat aging as a medical condition have come and gone over the years. Longevity.Technology is one o...
Senescent Astrocytes May Negatively Affect the Function of Neurons
A good deal of evidence points towards cellular senescence in the supporting cells of the brain, such as astrocytes and microglia, as an important contribution to neurodegeneration, cognitive decline,...
Sucrase-Isomaltase Deficiency as a Health-Inducing Mutation
Researchers here note that the uncommon sucrase-isomaltase deficiency found in some Greenland populations may be generally beneficial to long-term health in adults, removing many of the downsides to i...
Fight Aging! Newsletter, January 3rd 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly ...
A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an...
Red Meat Increases Cardiovascular Risk via Raised TMAO Production by the Gut Microbiome
More research into aging and the gut microbiome is taking place these days. A greater investment into this line of research will, as illustrated here, likely lead to a greater knowledge of the mechani...
Inflammatory Microglia Impede Myelination in the Aging Brain
Myelin sheathing of the axons connecting neurons is essential to the correct function of the nervous system. It is maintained by oligodendrocyte cells, but as noted in this open access paper, the main...
Towards More Broadly Effective Influenza Vaccines
Might it be possible to develop a vaccine that works on every strain of influenza, rather than going through a seasonal exercise of vaccination every year? Or at least many strains, rather than just a...
The Chronic Inflammation of Aging Interferes in Muscle Metabolism
Researchers here discuss some of the details of the disruption of muscle metabolism caused by inflammation in aging. With advancing age, the immune system becomes ever more overactive and dysfunctiona...
Towards a Theory of Autophagy Thresholds for Optimal Lifestyle Choices
The authors of this open access paper take an interesting position on the use of lifestyle choices to slow aging. In their view the most important outcome is an increase in the efficiency of autophagy...
Cardiorespiratory Fitness Slows Structural Changes in the Aging Brain
Today's open access paper discusses recent data on age-related changes in brain structure, assessed in older people with varying degrees of physical fitness, though all were described as inactive. Bra...
Another Large Longevity-Focused Venture Fund in Europe
A sizable amount of venture capital has emerged to support the longevity industry over the last year. The Korify Capital fund noted here is the latest of a series of longevity-focused funds to be anno...
Frailty is a Risk Factor for Dementia
Age-related frailty is characterized by physical weakness and chronic inflammation, but this is the visible tip of the iceberg. Chronic inflammation accelerates much of the dysfunction of aging. As re...
Plagl2 / Dyrk1a Gene Therapy Restores Youthful Behavior of Neural Stem Cells
In today's open access paper, the authors report on a successful effort to restore youthful behavior in neural stem cell populations in aged mice. A lentiviral gene therapy to upregulate plagl2 and do...
The Failure of Mitophagy as a Contributing Cause of Sarcopenia
Here, researchers discuss the role of mitochondrial quality control in sarcopenia. Sarcopenia is the name given to the later stages of the loss of muscle mass and strength characteristic of aging. Mus...
Novel Approaches to Protect the Heart Following Injury
Researchers here discuss potential approaches to protect the heart from scarring and loss of function following a heart attack: senolytics to clear senescent cells; restoration of mitochondrial functi...
Senolytic Treatment Improves Muscle Regeneration in Old Mice Only
Senescent cells accumulate with age. Researchers here provide evidence for yet another age-related decline to be added to the long list of issues in which this accumulation of senescent cells is an im...
What is Known of the Reasons Why Aging Stem Cells Lose their Regenerative Capacity
Declining stem cell function is undoubtedly an important contribution to degenerative aging and age-related mortality. Tissues require the supply of new somatic cells that is generated by stem cells i...
Lower Hemoglobin Levels Correlate with Raised Mortality in Older People
Anemia is a lowered level of red blood cells and hemoglobin, leading to a diminished supply of oxygen to tissues and thus degraded function throughout the body. The anemia of aging, like all issues in...
Fight Aging! Newsletter, December 27th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly ...
Nicotinamide Mononucleotide Supplement Adjusts the Gut Microbiome
In today's open access paper, the authors report on their investigation of the effects of nicotinamide mononucleotide (NMN) supplementation on the gut microbiome in mice. The gut microbiome changes wi...
Sirtuins Remain an Active Area of Research in Aging
Sirtuins are connected to the upregulation of cellular stress response mechanisms triggered by, for example, calorie restriction. Given the failure of past attempts to intervene in aging at the point ...
Imflammasome Induced Cellular Senescence
Researchers here show that signaling related to inflammatory regulation within a cell, undertaken in response to stress, can induce cellular senescence. Preventing the onset of the senescent state in ...
What is the Contribution of Demyelination to Cognitive Decline in Aging?
Myelin is an insulator that sheaths the axons forming nervous system connections. It is essential to the correct electrochemical function of the nervous system. Severe conditions such as multiple scle...
Dry Commentary on the Collision of Increasing Lifespan and Myopic Economic Regulation
Enforced retirement is a great iniquity, in those countries where it exists. This is true of any attempt by the powers that be to thrust their idea of how a life should be lived onto tens of millions ...
A Hair Follicle is a Complex Structure, Still Comparatively Poorly Understood
Why hasn't the research and development community achieved greater progress towards solving the problem of hair loss with age, given the sizable interest in achieving this goal? One possible answer is...
